Five members of a tough Special Forces unit are double crossed and framed for the murder of a group of Bolivian children. Clay (Jeffery Dean Morgan), Jensen (Chris Evans), Roque (Idris Elba), Pooch (Columbus Short) and Cougar (Oscar Jaenada) fake their deaths and plan to get their revenge on a man only known by the name of Max (Jason Patric). The men stay hidden and live their lives in Bolivia until Clay meets a mysterious woman named Aisha (Zoe Saldana), who wants revenge on Max as well. She helps the team get back to the United States and they stay deep undercover as they try to track down Max, which is a very difficult task because he is heavily guarded at all times. Max is a rogue CIA agent who is evil and ruthless and determined to cause a new high-tech global war. “The Losers” must get their revenge and stop Max from causing destruction all at the same time.